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Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.Dosage - Oral: Children 6-11 years: 30 mg twice daily Children /= 6 years and Adults: 10 mg once daily Elderly: Peak plasma levels are increased; elimination half-life is slightly increased; specific dosing adjustments are not available Dosage adjustment in renal impairment: Clcr /= 6 years and Adults: 10 mg every other day Supplied Syrup (Claritin®): 1 mg/m L (120 m L) [contains sodium benzoate; fruit flavor] Tablet (Alavert™, Claritin®, Claritin® Hives Relief; Tavist® ND): 10 mg Tablet, rapidly-disintegrating: 10 mg Alavert™: 10 mg [contains phenylalanine 8.4 mg/tablet] Claritin® Redi Tabs®: 10 mg [mint flavor] Dimetapp® Children's ND: 10 mg [contains phenylalanine 8.4 mg/tablet] (pseudoephedrine 120mg fexofenadine 60mg).Mechanism of Action Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects.

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[see Warnings and Precautions (5.5)] Adults and Adolescents 12 years of age and older: 7.5 m L to 20 m L (6 to 16 mg) every 12 hours Children 2 to 11 years of age (approximately 0.2 to 0.4 mg/kg/day): 2 to 3 years: 3.75 m L to 5 m L (3 to 4 mg) every 12 hours 4 to 5 years: 3.75 m L to 10 m L (3 to 8 mg) every 12 hours 6 to 11 years: 7.5 m L to 15 m L (6 to 12 mg) every 12 hours HOW SUPPLIED: Extended-release oral suspension containing 4 mg carbinoxamine maleate per 5 m L Adult (usual): 4 mg po every 4 to 6 hrs; maximum dose: 24 mg/day.

Sustained-release: 8 or 12 mg po every 8 to 12 hours. Supplied: Extended Release Cap: 6 mg, 8 mg, 12 mg Liquid/syrup: 2 mg/5 ml Tablet: 2 mg, 4 mg.

[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.

Mechanism of Action Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.

Please see package insert for additional information and possible updates.

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