Thurman next starred with Janeane Garofalo in the romantic comedy The Truth About Cats & Dogs as a ditzy blonde model.In 1997, she starred opposite Ethan Hawke in Gattaca, a science fiction film set in a future society driven by eugenics where potential children are conceived through genetic manipulation to ensure they possess the best hereditary traits of their parents.
She has performed in a variety of films, ranging from romantic comedies and dramas to science fiction and action movies.
Following her appearances on the December 1985 and May 1986 covers of British Vogue, she starred in Dangerous Liaisons (1988).
The film saw her play the female lead and love interest of Timothy Hutton's character.
Despite modest box office returns, the film was favorably received by the critics, who praised the script and acting, particularly that of Hutton and Portman.
She made her movie debut in 1988, appearing in four films that year.